Differin 0.1% Gel is a topical (skin-applied) gel containing the retinoid adapalene, the first acne-fighting active component available over the counter in over three decades. Adapalene is a third-generation topical retinoid predominantly used to treat mild to moderate acne. Adapalene cures acne deep in the pores, prevents new acne from forming, and restores your skin's natural texture and tone. It may reduce the frequency and severity of acne pimples while also promoting rapid healing of any pimples that do occur.