Optimistic glutacosamine, chondroitin, and MSM combo: the best for strong, healthy joints! Supplements containing glucosamine are used to help stop joint tissue deterioration and the pain, stiffness, and weakness that come with it. By collecting liquid, especially water, from the bones, chondroitin maintains the health of the joints. MSM offers a nutritional source of sulfur, and the skin, muscles, and bones contain half of the sulfur in the body. An essential building component, sulfur improves suppleness and fortifies joint tissues.