Glucophage 500mg Tablet (Pack of 50) is an oral antidiabetic medicine by Merck containing metformin hydrochloride 500mg per film-coated tablet, prescribed as a first-line treatment for type 2 diabetes mellitus (T2DM) in adults and children aged 10 years and above. Supported by over 60 years of clinical evidence and endorsed in major international diabetes guidelines - including those from the International Diabetes Federation and the American Diabetes Association - Glucophage 500mg helps lower both fasting and postprandial blood glucose levels, supporting long-term metabolic health when combined with diet and exercise.

How It Works

Metformin hydrochloride, the active ingredient in Glucophage 500mg, works through three complementary mechanisms. It reduces hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis in the liver. It slows intestinal glucose absorption, reducing postprandial blood sugar spikes. It also improves peripheral insulin sensitivity, helping the body's own insulin work more effectively. Crucially, metformin does not stimulate insulin secretion directly, which means it carries a low risk of hypoglycaemia when used as monotherapy.

Important Information

Glucophage 500mg is a prescription-only medicine. Always consult your healthcare provider before starting, adjusting, or stopping this medication. Glucophage is contraindicated in patients with significant renal impairment (eGFR below 30 mL/min/1.73m2), hepatic impairment, acute metabolic acidosis, or dehydration. Renal function (eGFR) should be assessed before initiation and at least annually during treatment. A rare but serious risk - lactic acidosis - can occur if used inappropriately; seek immediate medical attention if you experience unusual muscle pain, difficulty breathing, or severe abdominal discomfort. Store at room temperature, away from moisture and direct sunlight.