Merck
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Description
Overview: Glucophage XR 750mg utilizes Metformin Hydrochloride in an extended-release delivery system to improve glycemic control in adults with type 2 diabetes mellitus. It functions by reducing hepatic glucose production, decreasing intestinal glucose absorption, and enhancing insulin sensitivity through increased peripheral glucose uptake and utilization.
Dosage & Administration
- Dosage: 1 tablet (750mg) per administration, unless otherwise directed by a healthcare professional.
- Frequency: Once daily.
- Method: Swallow whole; do not crush, chew, or break the tablet to maintain extended-release integrity. Administer with 200ml of water.
- Timing: Consume with the evening meal to minimize gastrointestinal side effects and align with nocturnal glucose regulation.
- Titration: Maximum recommended dose is 2000mg per day (not exceeding 2 tablets of the 1000mg strength or equivalent).
Safety & Storage
- Storage: Store at controlled room temperature below 30°C. Protect from moisture and light.
- Warning: Risk of Lactic Acidosis. Discontinue use immediately during clinical states associated with hypoxemia or severe dehydration.