Janumet 50mg/500mg is a fixed-dose combination pharmacotherapy containing Sitagliptin and Metformin Hydrochloride. This medication provides physiological support for the management of type 2 diabetes by utilizing two synergistic mechanisms: Sitagliptin (a DPP-4 inhibitor) increases insulin synthesis and decreases glucagon secretion, while Metformin (a biguanide) reduces hepatic glucose production and improves peripheral insulin sensitivity.

Dosage & Administration

• 1 tablet per dose.
• 2 times per day.
• Administer orally with meals to mitigate gastrointestinal distress and optimize glycemic control.
• Swallow whole with a full glass of water.
• Do not crush or chew the tablets; maintain the integrity of the film coating for proper absorption.

Safety & Storage

• Boxed Warning (Lactic Acidosis): Metformin accumulation can lead to fatal lactic acidosis.
• Adverse Reactions: Common side effects include diarrhea, nausea, flatulence, and headache. Monitor for severe abdominal pain as a symptom of pancreatitis.
• Storage: Store in original packaging at controlled room temperature below 30°C. Protect from light and moisture.