This synthetic vitamin D analog contains calcitriol, the physiologically active form of cholecalciferol, which functions as a potent hormone in the regulation of calcium and phosphorus homeostasis. Unlike inactive vitamin D precursors, this medication does not require hepatic or renal hydroxylation, making it effective for patients with impaired kidney function. The 0.25mcg soft gelatin capsules facilitate the active transport of calcium across the intestinal mucosa and increase tubular reabsorption of calcium in the kidneys. By stimulating bone resorption and mineralization, the formulation helps manage secondary hyperparathyroidism and metabolic bone disease. It is clinically indicated for patients undergoing continuous renal dialysis and those with hypocalcemia associated with hypoparathyroidism.
Dosage and Administration
Metric | Specification |
Standard Dosage | 0.25 mcg (1 capsule) |
Active Ingredients | Calcitriol (Synthetic 1,25-dihydroxyvitamin D3) |
Timing | Once daily, typically in the morning |
Method of Use | Oral administration; swallow capsule whole |
Storage and Safety
Parameter | Specification |
Storage Temperature | Store at controlled room temperature (15°C – 30°C) |
Environmental Protection | Protect from light and moisture; keep container tightly closed |
Clinical Monitoring | Requires regular serum calcium, phosphorus, and creatinine testing |
Contraindications | Do not use in patients with hypercalcemia or vitamin D toxicity |
Key Features
- Biologically Active Form: Provides 1,25-dihydroxyvitamin D3, ensuring immediate physiological activity without the need for metabolic conversion by the liver or kidneys.
- Intestinal Calcium Transport: Directly stimulates the synthesis of calcium-binding proteins in the enterocytes to enhance dietary calcium absorption efficiency.
- Parathyroid Suppression: Effectively reduces elevated serum levels of parathyroid hormone (PTH) to mitigate bone turnover and renal osteodystrophy.
- Rapid Pharmacokinetics: Reaches peak plasma concentrations within 3 to 6 hours, allowing for precise control over serum calcium levels through titrated dosing.
- Bone Mineralization Support: Promotes the mobilization of calcium and phosphate from bone tissue into the systemic circulation to maintain skeletal integrity.