Xigduo XR is a fixed-dose combination medication containing Dapagliflozin and Metformin Hydrochloride Extended-Release. This medication provides physiological support for the management of type 2 diabetes by combining two complementary mechanisms: Dapagliflozin (an SGLT2 inhibitor) promotes the excretion of glucose through the urine, while Metformin (a biguanide) reduces glucose production in the liver and improves peripheral insulin sensitivity.

Dosage & Administration

• 1 tablet per dose.
• Frequency: Once daily, typically in the morning.
• Timing: Administer orally with a meal to reduce the risk of gastrointestinal side effects associated with high-dose Metformin.
• Swallow whole: Do not crush, chew, or break the tablets. The extended-release (XR) delivery system relies on the tablet remaining intact to release the medication gradually over 24 hours.
• Hydration: Maintain adequate fluid intake to support the mechanism of glucose excretion through the kidneys and prevent dehydration or volume depletion.

Safety & Storage

• Boxed Warning (Lactic Acidosis): Metformin accumulation can lead to lactic acidosis; risk increases with renal impairment, aging, and excessive alcohol consumption.
• Adverse Reactions: Common side effects include nausea, diarrhea, increased urination, and nasopharyngitis.
• Storage: Store at room temperature below 30°C. Keep in the original container to protect from moisture.