Zavzpret is the first and only calcitonin gene-related peptide (CGRP) receptor antagonist nasal spray indicated for the acute treatment of migraine with or without aura in adults.1 By delivering the active ingredient directly through the nasal mucosa, it bypasses the digestive system to provide rapid pain relief, often within 15 to 30 minutes, making it an ideal solution for patients who experience migraine-associated nausea or vomiting.
Key Features
- Rapid Absorption Path: The nasal delivery system allows for high bioavailability and a faster onset of action compared to traditional oral triptans or gepants.
- CGRP Receptor Blockade: Unlike older migraine medications that constrict blood vessels, Zavzpret works by blocking CGRP receptors, which are known to play a key role in the inflammatory and pain signaling pathways of a migraine attack.
- Nausea-Friendly Delivery: As a nasal spray, it is an effective alternative for patients who cannot tolerate oral medications during an attack due to gastric stasis or severe nausea.
- Sustained Relief: Clinical trials demonstrate that many patients experience freedom from their most bothersome symptoms (MBS), such as light or sound sensitivity, for up to 48 hours post-dose.
- Single-Use Precision: Each unit is a non-refillable, single-dose device, ensuring the delivery of exactly 6$10\text{mg}$ of Zavegepant per application.
Recommended Usage
Use exactly as prescribed by your doctor. The recommended dose is a single spray (8$10\text{mg}$) into one nostril.9 Do not prime the device before use, as it contains only one dose.10 If the migraine returns, a second dose should not be taken within a 24-hour period. Safety for treating more than 8 migraines in a 30-day period has not been established.11