Berberine is an alkaloid found in a variety of plants, including goldenseal, barberry, Oregon grape, and goldthread. These plants have a long history of use in a number of ways to promote human health.

Berberine may be made from a variety of plant components, including seed, bark, root, and so on. Enzymedicas Berberine is unusual in that it is a totally renewable and sustainable substance derived from barberry seeds.